Tyrosinase?mediated hydrogel crosslinking for tissue engineering

Hydrogel system based on enzyme-mediated mild crosslinking reaction has been a promising approach in tissue engineering. Inspired by skin melanin synthesis and marine mussel adhesion, tyrosinase-mediated hydrogel exploited as cell-friendly reactions explicit mechanisms. prepared tyrosinase exhibits appealing properties dynamic scaffold for cell delivery bioink 3D bioprinting. Recapitulating the structure of native extracellular matrix (ECM), innovative now shifted to field translational medicine. Biomimetic with situ can be efficiently easily applicable disease model therapeutic purposes. In this review, we will discuss broad range engineering from specific mechanism designing strategy applications addition, report current challenges future perspectives applications.